乙型肝炎患者HBV-DNA与血清e系统的关系

The relationship between HBV DNA and e antigen system in serum in patients hepatitis B

目的 :探讨乙型肝炎患者HBV DNA与血清e系统的关系。方法 :用PCR和ELISA法分别检测 135例急、慢性乙型肝炎患者血清中HBV DNA和HBsAg、抗 HBs、HBeAg、抗 HBe、抗 HBc。结果 :e抗原阳性组与e抗体阳性组 ,HBV DNA阳性率差异有显著性 (P <0 .0 1) ;但与各临床类型间差异无显著性 (P >0 .0 5 )。结论 :HBV DNA阳性多见于活动性乙型肝炎患者 。

Objective:To study the relationship between HBV DNA and e antigen system in serum in patients with hepatitis B.Methods:HBV DNA and HBsAg、HBsAb、HBeAg、HBeAb、HBcAb in serum of 135 patients with acute and chronic hepatitis B were tested by polymerase chain reaction(PCR) and enzyme linked immunosorbent assay(ELISA).Results:There was higher significant difference for positive rate of HBV DNA between in the group of HBeAg(+) and in that of anti HBe(+)( P <0.01);but there was no significant difference among clinical types ( P >0.05).Conclusions:HBV DNA positive was common in active hepatitis B and tighly related to the expressive level of HBeAg.