三峡库区移民幽门螺杆菌感染的流行病学研究

A study on the epidemiology of Helicobacter pyroli infection among immigrants in Three Gorges area

目的 了解三峡库区移民幽门螺杆菌感染的血清流行病学状况。方法 通过移民流行病学病例对照方法 ,应用酶联免疫吸附试验 ,对三峡库区 16 0 0名移民与 16 0 0名非移民的幽门螺杆菌(Hp)感染状况进行研究。结果 移民区Hp感染率 (6 7.5 0 % )明显高于非移民区Hp感染率(5 3.19% ) (χ2 =13.40 ,P <0 .0 1)。婴儿期Hp感染率较高 ,儿童期开始下降 ,随年龄增加 ,又开始上升 ,与年龄呈显著正相关 (r =0 .6 2 ,P <0 .0 5 )。移民区与非移民区的Hp感染率女性高于男性 ,经统计学处理 ,差异无显著性。文化程度越低 ,Hp感染率越高 (P <0 .0 1)。一期水位淹没区移民Hp感染率明显高于二期与三期水位淹没区移民Hp感染率 (P <0 .0 1)。结论 三峡库区移民区移民Hp感染率高于非移民区居民Hp感染率 ,生活环境、文化教育程度等因素可能起着重要影响 ,库区儿童Hp感染率较高 ,对于库区移民儿童Hp感染的预防尤为重要。通过移民搬迁与移民政策的实施 ,改善经济水平与文化教育程度 ,能否降低移民Hp感染率 。

Objective To investigate the epidemiologic features of Helicobacter pyroli (Hp) sero prevalence rates among immigrants in Three Gorges area. Methods Enzyme labelled immuno sorbant assay was used to determine the Hp prevalence rate.A case control study including 1 600 immigrants as cases and 1 600 non immigrants as controls was carried out to explore the features of Hp infection in Three Gorges area. Results The prevalence rate of Hp in immigrant area was 67.50 % higher than 53.19 % that of Hp in non immigrant (χ 2= 13.40 , P < 0.01 ). Rate of Hp infection was highest in infants than in children, increasing with age to clearly show a positive correlation between age and Hp prevalence rate( r = 0.62 , P < 0.01 ). However,there was no marked sex difference in Hp infection rates in the immigrant area. Same results were also presented in the non immigrant area. Hp prevalence rates were different which related to the stages of flooding. It is 89.17 % in the area of first stage, while in second and third stages of flooding, the rates were 76.40 % and 62.20 % respectively. Conclusion Preliminary result indicated that Hp infection rate of immigrant area was higher than that of non immigrant area. It appeared that living condition,environment,education condition might possibly have played important role in Hp prevalence. It is more important to prevent from infected children. Further study with respect to Hp prevalence rate was necessary when immigration is completed and the standard of living improved.