甲磺酸左氧氟沙星在肺结核患者体内的药代动力学研究

Pharmacokinetics of levofloxacin methane sulfonic acid in patients with pulmonary tuberculosis

目的 研究甲磺酸左氧氟沙星口服给药后在肺结核患者体内的药代动力学特性。方法 采用高效液相色谱法测定血清中甲磺酸左氧氟沙星浓度 ,以 3P97药代动力学程序计算药代动力学参数。结果 8例肺结核患者po 40 0mg甲磺酸左氧氟沙星后 ,体内过程符合一室开放模型。tmax为 1.2 2h ,cmax为 (4.5 2± 0 .72 )mg·L-1,一次给药 2 4h后血药浓度为 (0 .5 2± 0 .2 6 )mg·L-1,AUC为 (48.35± 5 .38)mg·h·L-1,t1/ 2 为 (6 .49± 1.70 )h ,V/F(c)为 (77.48± 8.33)L。结论 肺结核患者服用甲磺酸左氧氟沙星 ,推荐每次 40 0mg ,每日二次的服药方法。对肝肾功能不全的患者 ,防止出现不良反应。

OBJECTIVE To study the pharmacokinetics of levofloxacin methane sulfonic acid (LF MSA)in 8 patients with pulmonary tuberculosis after administration 400 mg orally.METHODS The concentrations of LF MSA in serum were measured by HPLC.The pharmacokinetic paramters were obtained using 3P97 program.RESULTS The results showed that a one compartment model with 1 st order absorption were fitted for LF MSA.The average values of t max was 1.22 h.The concentrations of LF SA in serum was (4.52±0.72) mg·L -1 .The mininal concentrations of LF AS at 24 hr after a single dose was (0.52±0.26) mg·L -1 .The average area under the curve was (48.35±5.38) mg·h·L -1 .The elimination half life was (6.49±1.70) h.The apparent volume of distribution was (77.48±8.33)L.CONCLUSION According to our study,it was suggested that 400 mg twice daily may be given in order to maintain the concentrations of LF SA in serum around 24 hours above the minimal concentrations of bactericide.