四氯化碳致大鼠肝纤维化模型血液流变学性质的研究

Study on hemorheological changes of carbon tetrachloride(CCl_4)induced hepatic fibrosis in rat

目的 :研究大鼠肝纤维化时血液流变学性质的变化特征。方法 :以四氯化碳诱导大鼠肝纤维化模型 ,检测血液粘度、血浆粘度、红细胞压积、红细胞特性指数等血液流变学参数 ,分析其变化特征。结果 :与正常组比较 ,模型组大鼠全血粘度、全血还原粘度、血浆粘度、红细胞压积、红细胞聚集指数及红细胞刚性指数明显增高。结论 :大鼠肝纤维化时血液粘度增大 ,红细胞流变性能减弱 ,易引发微循环障碍 。

OBJECTIVE:To study the hemorheological paramenters in rat with hepatic fibrosis. METHODS:Hepatic fibrosis in rat was induced by CCl 4 treatment. Whole blood viscosity, plasma viscosity, Hematocrit(Hct) and dynamic parameters of red blood cell(RBC) were investigated. RESULTS:As compared with the normal group, the hemorheological parameters such as whole blood viscosity, plasma viscosity, Hematocrit(Hct), RBC's aggregation and rigidity were increased obviously. CONCLUSION:High blood vicosity and low RBC's deformation ability can lead to blood circulation obstacle, thus will aggravate hepatic fibrosis.