双戊烯对替硝唑透皮吸收促进作用的研究

Enhancement effect of dipentene in the transdermal absorption of tinidazole

目的 :研究双戊烯对替硝唑的促透效果 ,为透皮促进剂的选择提供参考。方法 :通过离体小鼠皮肤渗透释药实验 ,测定含不同浓度双戊烯和氮酮对替硝唑溶液促透效果。结果 :不同浓度促透剂对替硝唑的透皮吸收促进效果大小顺序为 3%双戊烯 >2 %双戊烯≈ 4 %氮酮 >3%氮酮。结论 :3%双戊烯对替硝唑溶液有显著的透皮促进作用 ,与其他浓度的双戊烯和氮酮相比具有显著差异 (P <0 .0 5)

OBJECTIVE:To study the enhancement effect of dipentene in the transdermal absorption of tinidazole.METHODS:In vitro,using side-by-side diffusion cells determines the diffusion of tinidazole across excised mouse skin to compare the enhancement effect of dipentene with Azone at different concentrations in the transdermal absorption of tinidazole.RESULTS:Enhancement effects at different concentrations were following:3% dipentene >2% dipentene≈4%Azone>3% Azone.CONCLUSION:It is showed that various concentrations of transdermal enhancers could promote absorption of tinidazole in different degrees and 4% Azone and 3% dipentene are the most effective.