程序升温色谱法同时测定中成药痰咳净中冰片和咖啡因

Simultaneous Determination of Borneol and Caffeine in Chinese Prepared Medicine Tan Kejing by Program- ming Temperature Gas Chromatography

痰咳净是一种新型快速排痰镇咳中成药。由桔梗、北杏、冰片、咖啡因、甘草等多种药物组成。冰片和咖啡因是制剂中具有多种药理作用的重要成分,因此,测定两者的含量对控制和评定产品质量以及对卫生部规定的一类管理药物咖啡因的审定有着十分重要的意义。 分别测定冰片和咖啡因的气相色谱法已屡见报道。采用色谱法同时测定这两种成分,国内外未见报道。本文介绍程序升温气相色谱法同时测定冰片和咖啡因。实验表明,本法操作简便、迅速,准确度和重现性良好。

A procedure for simultaneous analysis of borneol and coffeine in the Chinese prepared medicine Tan Kejing is presented. Both ingredients were extracted with CHCl3 and then directly determined by programming temperature gas chromatography. It is a simple, rapid and accurate method.