F_(344)大鼠癌前期病变组织中γ-谷氨酰转肽酶、甲胎蛋白的表达

THE EXPRESSION OF GAMMA-GLUTAMYLTRANSPEPTIDASE AND ALPHA FETOPROTEIN IN PRENEOPLASTIC LESIONS IN FISCHER 344 RATS

应用丫-谷氨酰转肽酶-甲胎蛋白(GGT-AFP)双染色法对F_(344)大鼠癌前期病变组织中GGT,AFP的产生细胞进行研究.结果表明,透明细胞结节、嗜酸性细胞结节GGT阳性,AFP阴性;嗜碱性细胞结节GGT阴性,部分结节AFP阳性;不典型增生细胞两者均阴性.提示增生结节及肝癌来源于小肝细胞及散在的AFP阳性细胞.

Gamma-glutamyltranspeptidase (GGT) and alpha fetoprotein(AFP) producing cells in preneoplastic lesions in F_(344) rats were studied by means of double staining of GGT anp AFP.The results showed that clear cell nodules and acidophilic cell nodules stained for GGT and not for AFP. Basophilic cell nodules did not stain for GGT, some of them contained AFP.Liver cell dysplasia contained neither GGT nor AFP.Proliferative nodules and hepatocellular carcinoma originated from small hepatocytes and the scattered AFP positive cells.