Ⅱ型糖尿病空腹血糖与胰岛素分泌功能的相关性研究

STUDY OF THE RELATIONSHIP BETWEEN INSULIN SECRETION AND FASTING GLUCOSE LEVEL IN TYPE Ⅱ DIABETES MELLITUS

对94例Ⅱ型糖尿病(NIDDM)患者的空腹血糖水平与胰岛素分泌功能进行对照性研究发现,口服葡萄糖耐量试验2h内平均胰岛素分泌量正常者52例(55.32%),降低者39例(41.5%),升高者3例(3.19%).葡萄糖负荷后胰岛素反应的不均一性与病人空腹血糖水平有关,随空腹血糖升高,平均胰岛素分泌量呈先升高后降低的变化趋势.从而提示,轻型或早期NIDDM患者的病理生理异常主要在于周围组织对胰岛素的抵抗,而胰岛素分泌功能保持相对正常;对于空腹血糖明显升高者,胰岛素分泌功能降低则较为突出,对这部分病人应给予胰岛素治疗.

Among 94 patients with type Ⅱ diabetes mellitus (NIDDM), the mean insulin secretion during a 2-hour oral glucose tolerance test (OGTT) was normal in 52 (55.32%), low in 39 (41.5%) and high in 3 (3.19%). The heterogeneity of insulin response during glucose load was well correlated with the fasting glucose level. As the fasting glucose increases progressively, the mean insulin secretion after OGTT presents an inverted U-shaped curve. The results indicate that the insulin resistence may be the central pathogenicity for the NIDDM patients with a fasting glucose below 6.72mmol/L and their insulin secretion is relatively normal, whereas the deficiency of insulin secretion is so significant for the NIDDM patients with a fasting glucose above 12.32mmol/L that insulin therapy is needed