摘要
6名老年与6名年轻健康志愿者肌内注射丁胺卡那霉素7．5mg/kg后，老年组经1．04g达血药峰深度23．54±2．98μg/ml，年轻组经0．99h达峰浓度20．7722．38μg/ml，老年组与年轻组7h后血浆中浓度分别为5．24μg/ml和1．97μg/ml，按开放一室模型拟合算得，消除半衰期分别为2．31±0．56h和1．58±0．28h（P＜0．05），表观分布容积分别为0．235±0．026L／kg和0．239±0．010L／kg，老年组和年轻组24h尿排泄原药分别为74．3±12．2％和75．4±8．1％，肾清除3率分别为61．93±24．30ml/min和84．63±25．41ml/min。结果表明，丁胺卡那霉素老年人消除比年轻人要慢。
Pharmacokinetic parameters of amikacinwere determined in 6 aged. and 6 young healthyvolunteers after single intramuscular injectionof 7.5mg/kg. The aged had a peak serum le-vel of 23.54 ± 2.98μg/ml after 1.04 hours, wher-eas the young men had a peak serum level of20.77 ± 2.38μg/ml after 0.99 hours. In the agedand young groups, serum level was 5.24μg/ml and 1.97μg/ml respectively after 7 hours.After calculation with one-compartment openmodel, the elimination half-life (t_(1/2)) for thetwo groups was 2.31 ± 0.56 and 1.58 ± 0.28 hours respectively (P<0.05) and the apparentvolume of distribution was 0.235 ± 0.026 and0.239 ± 0.010L/kg respectively. The urinary rec-overy rate by 24 hours after injection in the ag-ed and young groups was 74.3 ± 12.2% and 75.4± 8.1% respectively, and the renal clearancewas 61.93 ± 24.30 and 84.63 ± 25.41ml/min. Theresults demonstrated that the elimination ofamikacin was slower in the aged than in theyoung.
出处
《中国药学杂志》
CAS
CSCD
北大核心
1990年第1期18-21,共4页
Chinese Pharmaceutical Journal
