摘要
本文采用研究造血祖细胞的常规方法,在体内或体外实验的条件下,研究了平阳霉素和异搏定单独或联合使用对造血祖细胞的影响。结果表明,体外分别试验平阳霉素和异搏定时,它们均能抑制造血祖细胞的增殖,两者合用能加强这种抑制作用。体内试验时开始对造血祖细胞有一定抑制作用,后有明显的刺激作用。这些结果将为临床上如何合理使用平阳霉素与异搏定提供一些依据。
We had studied the effect of pingyangmycin (PYM) and verapamil (VP) on murine haematopoietic progenitor cells in vivo and in vitro.It was found that VP enhanced the inhi- bitory action of PYM on the growth of murine CFU-GM,CFU-E,BFU-E,CFU-Meg in vitro.But in vivo,when PYM was used in combination with VP they stimulated the growth of CFU-GM,CFU-E,BFU-E,GFU-Meg.These results provide a theoretical basis for the clinical utilization of PYM combined with VP to improve the curative effect.
出处
《军事医学科学院院刊》
CSCD
北大核心
1991年第4期241-245,共5页
Bulletin of the Academy of Military Medical Sciences
基金
国家自然科学基金(No.0388002)
关键词
平阳霉素
异搏定
造血祖细胞
钙拮抗剂
骨髓
抗癌药
pingyangmycin
verapamil
haematopoietic progenitor cells
CFU-GM
CFU-E
BFU-E
GFU-Meg
