自然人群中抗-HBc IgM的分布特点及其流行病学意义

DISTRIBUTION OF ANTI-HBc IgM IN NATURAL POPULATION AND ITS EPIDEMIOLOGIC SIGNIFICANCE

检测采自北京郊区某农村的469份健康人血清中的抗-HBc IgM,阳性率为13.9%。单项抗-HBc IgM 的阳性率为9.2%,HBsAg 阳性者抗-HBc IgM 的阳性率为51.8%;HBsAg 阴性的 HBV 感染者抗-HBc IgM 的阳性率为12.1%。HBsAg 阳性者的抗-HBc IgM 阳性率显著高于 HBsAg 阴性者。分析结果表明,在 HBV 隐性感染者中,抗-HBcIgM 不仅是 HBV 急性感染的标志,也可以长期存在,标志着机体对 HBV 的免疫反应或 HBV 的复制。对抗-HBc IgM 的临床意义还应进行深入研究。

In order to understand the distribution of anti-HBc IgM in natural population,469 serum samples obtained from a village in rural area of Beijing were tested for anti-HBc IgM.The positivity rate of anti-HBc IgM was 13.9% in the whole population,it was 51.8% in the HBsAg positive persons;12.1% in those of HBV infected who were HBsAg negative.The rate of anti-HBc IgM positive alone was 9.2%.The positivity rate of anti- HBc IgM in HBsAg positive persons was significantly higher than that of those HBsAg negative.Analysis showed that in those of HBV inapparent infected persons,anti-HBc IgM was a serum marker indicating not only HBV acute infection,but also HBV immunization or duplication,it can be persistent for a long time.