摘要
参照Labrecque等提取肝细胞刺激物质(HSS)的方法,从新生牛肝脏中提取出分子量小于1.98万u的生物活性物质,动物试验表明,该物质对D-氨基半乳糖(D-Gal)所致的急性肝衰竭大鼠的存活率有明显的提高,并对大鼠肝细胞DNA合成有明显的促进作用。
The therapeutic effects of bovine hepatocytic growth factor ( BHGF ) were studied on acute hepatic failure ( AHF ) induced by D-galactosamine ( D-Gal ) in rats. The BHGF was isolated from the hepatic cytosol of newborn cow in our laboratory and its molecular is under 20 000 dalton. The results showed that. l)the survival rate of the rats with AHF was significantly enhanced after therapy with BHGF, 2 ) the 8H-TdR were highly incoporated into hepatocytic DNA of the rats, 3 ) the pathological damage of the rat liver was obviously improved, when comparied with the control. It is Suggested that BHGF could stimulate the hepatocytic DNA synthesis and be effective in the therapy of AHF in rats.
出处
《中国药理学通报》
CAS
CSCD
北大核心
1991年第3期222-224,共3页
Chinese Pharmacological Bulletin
