摘要
采用静注垂体后叶素复制家兔心肌反复短暂缺血模型,观察了其对随后进行的急性心肌梗塞(AMI)再灌注过程中血小板和白细胞聚集性、心肌梗塞边缘区多形核粒细胞(PMN)浸润以及心肌梗塞范围的变化。结果显示,垂体后叶素所致心肌反复短暂缺血对AMI再灌注实验组的心肌梗塞范围、血小板聚集性和心肌梗塞边缘区PMN浸润数均大于或高于单纯AMI再灌注对照组。两组白细胞聚集性无明显差异,但处死前两组高于结扎前。提示垂体后叶素所致心肌反复短暂缺血对AMI再灌注具有累积性损伤效应,而血小板和白细胞活性增高可能在其累积性损伤中起重要作用。
Effects of repetitive transient myocardial ischemia induced oy repeated intravenous administration of pituitrin on the following infarct-reperfusion were studied in rabbits. The changes of blood platelet and leukocyte aggregation, polymorphonuclear neutrophil(PMN) infiltration in the margin of infarct and the infarct size were observed. Results showed that the myocardial infarct size and PMN infiltration in experimental group were higher than that in the control group (ligation of left main coronary artery)(P<0. 05). The patelet aggregation in experimental group were higher than that in the controi group both before oclusion and after 23rd hour reperfusion(P<0. 01). The leukocyte aggregation showed no differences between the two groups after 23rd hour reperfusion, but it appeared higher before oclusion ( P<0. 01,or P< 0. 05)in both groups. These suggested that the repetitive transient myocardial ischemia induced by repeated intravenous administration of pituitrin could produce a cumulative injury on acute myocardial infarctreperfusion. The actions of increased platelet aggregation and PMN infiltration may play an important role in this injury.
