内皮素与慢性肾小球肾炎及其水钠潴留关系探讨

Correlation between endothelin and chronicglomerulonephritis with sodium and waterretention

检测了伴或不伴水钠潴留慢性肾炎患者血浆内皮素（ｐＥＴ）和２４ｈ尿蛋白排泄量。结果发现，水钠潴留组ｐＥＴ（１７２．４８±４５．７７μｇ／Ｌ）显著高于无水钠潴留组（１０２．３３±２２．８２μｇ／Ｌ，Ｐ＜０．０１）和对照组（９４．７５±２０．４８μｇ／Ｌ，ｐ＜０．０１）；２４ｈ尿蛋白排泄量，水钠潴留组显著高于无水钠潴留组（９．６２±７．２５ｇ／Ｌ２．７８±２．３３ｇ／Ｌ，Ｐ＜０．０１），但尿蛋白排泄量与ｐＥＴ水平无明显相关。提示ＥＴ可能参与了慢性肾炎水钠潴留的病理机理，并影响着慢性肾炎的病理发展。

n patients with chronic glomeru-lonephritis (CG) with or without sodiumand water retention, the plasma endothelin(PET) and urinary protein excretion in 24 hhad been measured. It was found that thevalues of PET in sodium and watcr reten-tion group ( 172. 48± 45. 77μg/L) was muchhigher than the group without sodium andwater retention ( 102. 33±22. 82μg/L, P<0. 01 ) and controls (94. 75 ± 20. 48 μg/L ,P<0. 01). Proteinuria in 24 h in sodium andwater retention(9. 62±7. 25 g/L) was muchhigher than without sodium and water re-tention (2. 78±2. 33 g/L , P<0. 01 ) , but apositive correlation between proteinuria ex-cretion and PET hadn't been found. Theseresults indicated that ET might contributeto the pathogenesis in CG with sodium andwater retention and had an effect in pro-gression of CG.