螺旋藻多糖对移植性癌细胞的抑制作用及其机理的研究

INHIBITIVE EFFECT AND MECHANISM OF POLYSACCHARIDE OF SPIRULINA PLATENSIS ON TRANSPLANTED TUMOR CELLS IN MICE

螺旋藻多糖200mg/kg可显著抑制小鼠体内腹水型肝癌细胞的增殖。它对S180和腹水型肝癌细胞DNA,RNA和蛋白质的抑制作用,在3～24h内均随作用时间延长而提高。它对癌细胞DNA合成的抑制作用,属DNA代谢干扰型。螺旋藻多糖虽不能直接杀伤癌细胞,但通过增强机体的免疫力而抑制癌细胞的增殖。

Polysaccharide of Spirulina platensis can inhibit the proliferation of ascitic hepatoma cells of mice in the concentration of 200 mg/kg. It can inhibit the incorporation of 3H-thymidine, 3H-uridine and 3H-leucine into DNA, RNA and protein synthesis of sarcoma 180 and ascitic hepatoma cells during the period of 24 h after exposure in vetro. The degree of inhibition increases with the extending of incubation time. Polysaccharide of Spirulina pla-tensis can inhibit DNA synthesis of sarcoma 180 and ascitic hepatoma cells. The mechanism of inhibition belongs to DNA metabolism disturbance.