晶体源性眼内炎发病机理的实验研究——植物血凝素对晶体蛋白免疫耐受性的破坏作用

Phytohemagglutinin-triggered Experimental Lens-induced Endophthalmitis in Rats

依据植物血凝素(PHA)能激活多克隆T淋巴细胞的性质,先给大鼠注射PHA,再切开晶体囊膜,大鼠发生了晶体源性眼内炎。这个结果直接证实了T淋巴细胞在晶体源性眼内炎发病过程中起始动作用。这一动物模型建立时间短,不需接种弗氏佐剂,有助于探讨该病的发生机理和寻找治疗药物。

An experimental lens-induced endophthalmitis (LE) was produced after in jury to the lens of rats previously given i.p. with phytohemalglutinin(PHA).This result directly shows the starting role of T cell in the development of LE. The PHA-triggered LE is easily produced in a short period of time with out the need of injection of lens protein and Fr eund's adjuvant, therefore, it perhaps helps us further to study the mechanism of the disease and determine the effects of some drugs on modulating the inflammation in LE by this animal model.