赖氨酸对喂饲克山病病区粮大白鼠心肌细胞膜通透性的影响

Effect of lysine on permeability of myocardial sarcolemmal membrane in rats fed with grains from Keshan disease endemic area

用硝酸镧作示踪物研究大白鼠心肌细胞膜的通透性。结果证明用克山病病区粮喂饲的大白鼠心肌细胞膜通透性明显升高,表明细胞膜受到损伤。而在病区粮中加入赖氨酸,则可明显降低心肌细胞膜的通透性,对细胞膜有保护作用。同时证明加赖氨酸后使心肌内硒含量进一步降低,表明赖氨酸对细胞膜的保护作用并不是通过增加硒含量而实现的。本文对蛋白质缺乏与克山病发病的关系进行了讨论。

Effect of lysine on permeability of myocardial sarcolemmal membrane in rats fed with grains from Keshan disease endemic area was studied with lanthanum tracer, and the contents of six elements including K, Ca, Mg, Zn, Se and Mo in the myocardium were measured. The results indicated that permeability of myocardial sarcolemmal membrane in rats fed with grains from Keshan disease endemic area was markedly increased, showing injury of the sarcolemmal membrane; while that of rats fed with the same diet, but to which 0.2%L-lysine was supplemented was markedly decreased, with the content of Se in the myocardium not increased, suggesting that lysine did have a protective effect on the myocardium from injury induced by grains from Keshan disease endemic area, and that this effect was not the result of an increase of Se in the myocardium.