小儿外科感染时内毒素血症与Fn、CRP关系的研究

STUDIES ON THE RELATIONSHIP BETWEEN ENDOTOXEMIA AND PLASMA FIBRONECTIN OR C-REACTIVE PROTEIN IN PEDIATRIC SURGICAL INFECTIONS

为了解内毒素血症(ETM)与机体非特异性免疫功能的关系,同时测定外科感染患儿的血浆内毒素(Et)、血浆纤维结合蛋白(Fn)和血清C-反应蛋白(CRP)在手术前后的变化。结果提示外科感染时ETM与Fn、CRP的变化间存在一定的联系;ETM的形成和发展,与机休非特异性免疫功能的状态有关。本文还探讨了该三项指标的测定对病程监测及预后估计的意义。

The levels of plasma endotoxin, fibronectin (Fn) and C-reactive protein (CRP) were determined quantitatively in 36 children with bacterial peritonitis, 35 with unruptured acute appendicitis, 17 with soft tissue infection and 30 controls. The results showed: (1) Enodotoxemia leads to a decrease of plasma Fn and in return the depletion of plasma Fn would make endotoxemia more severe. (2) The determinaton of Fn and CRP together with the detection of endotoxin may be helpful to the diagnosis of peritonitis. (3) Serial determination of Fn is useful in monitoring the progress of diseasse. (4) The levels of endotoxin and Fn before operation are relatcd to the prognosis of patients.