内分泌—免疫系统相互关系的研究——Ⅱ.甲状腺素对体外小鼠脾淋巴细胞及胸腺细胞转化的影响

THE RELATIONSHIP OF IMMUNE SYSTEM AND ENDOCRINE SYSTEM——Ⅱ.THE EFFECT OF THYROXINE ON TRANSFORMATION OF MICE SPLEEN LYMPHOCYTE AND THYMOCYTE IN VITRO

以^3H-TdR 掺入法检测了甲状腺素在体外对正常小鼠脾淋巴细胞、S180荷瘤鼠脾淋巴细胞及胸腺细胞转化的影响，并对ConA刺激相应细胞转化的影响进行了研究。结果表明，甲状腺素对正常小鼠脾淋巴细胞、荷瘤鼠脾淋巴细胞及胸腺细胞的转化作用与对照组比较均有差异（P＜0．05，P＜0．01），甲状腺素可明显提高ConA刺激相应细胞转化，表明甲状腺素对机体细胞免疫有促进作用。

~3H-TdR incorporation technique was employed to study the effect of thyroxine on transformation of spleen lymphocyte in normal and in S_(180)tumor-bearing mice as well as the effect on these cells that was pro- duced by ConA stimulation.The results indicated that there was a markedly difference of transformation effect between the thyroxine treated group in-clude normal spleen lymphocyte of mice as well as the spleen lymphocyte and thymocyte of tumor-bearing mice(P<0.01,P<0.05,P<0.01).The result also shown that thyroxine can markedly increase the incorporation number of ~3H-TdR of these cells stimulated by ConA(P<0.01,P<0.001,P<0.01).Our study provide an evidance that thyroxine can enhance the cellulor immune effect and suggest an effect mechanism in the clinical applica-tion.