缺铁性贫血患儿铁剂治疗前后体内微量元素的变化

THE STUDY ON VARIATION OF SERUM TRACE ELEMENTS AROUND FERROTHERAPY IN CHILDREN WITH IRON DEFICIENCY ANEMIA

对缺铁性贫血(IDA)患儿进行了铁代谢指标及Fe,Cu,Zn,Ni,Pb,Cr,Cd等7种微量元素的测定。结果表明,IDA与低锌有因果关系,体内铁锌代谢密切相关,当IDA时体内需铁量增加,肠道吸收铁能力增强,竞争性地抑制了锌的吸收。铁剂治疗后,血清铁锌同时上升。提示治疗IDA伴低锌患儿单纯补铁剂提高体内铁储量可改善锌的吸收,提高血清锌水平,而不必另加锌剂,

Trace element of Fe,Cu,Zn,Ni,Pb,Cr,Cd and serum ferfi-t-in(SF),free erythrocyte protoporphyrin(FEP),hemoglobin(Hb)in serum of 334 cases of Jinan residents,ranging between 6 months to 6 years were determined,79 cases among them were found to be iron deficiency ane-mia(IDA)combined with significant decrease of serum Zn.43 of the 79 cases who cooperated well had been given oral irontherapy for 3 mo nth s.After ferrotherapy,not only SF,FEP and Hb regained normal level,but serum Fe and Zn inceased significantly as well.The result indicated that 1.IDA of a certain extent can lead to the decrease of Zn in serum.2.ferrotherapy alone can elevate serum Zn level in cases of IDA combined with low serum Zn.