摘要
本研究对中药复方大承气汤防治梗阻性黄疸时内毒素血症的作用进行临床观察。结果表明,中药防治组惠者术中门静脉血和术后体循环静脉血内毒素血症的发生率明显下降(P<0.01)。与中药防治组相比,黄疸对照组患者术后24小时内生肌酐清除率出现明显下降(P<0.01),纤维结合素水平也明显降低(P<0.01)。提示复方大承气汤对梗阻性黄疸时的内毒素血症具有良好的防治作用。
The role of Da Cheng Qi Decoction Co.(DCQDC)in preventing endotoxemia in obstructive jaundice has been investigated.A prospective study was performed on 43 consecutive patients with obstructive jaundice undergoing surgery.24 patients were given oral DCQDC before operation and were compared with 19 jaundiced control patients and 17 nonjaundiced control patients.The inci- dence of endotoxemia was reduced in perioperative portal(P<0.05)and postoperative systemic (P<0.01) blood samples in the DCQDC treated group,and a significant fall of the postoperative 24h creatinine clearance (P<0.01) and the plasma fibronectin level(P<0.01)occured in jaundiced controls compared with the DCQDC treated group.DCQDC may reduce endotoxin absorption by a reduction or alteration of gut flora thereby reducing the endotoxin pool available for absorption as well as by a direct effect on endotoxin.Result of this study indicated that DCQDC had a beneficial effect on endotoxemia or outcome in obstructive jaundice.
