复方丹参注射液对家兔低氧性肺血管收缩反应的影响

Effects of Salvia miltiorrhizae Composite Injection on Hypoxic Pulmonary Vasoconstriction in Rabbits

本实验观察了复方丹参注射液对低氧性肺动脉高压家兔肺循环、体循环、心电图 ST 段及动脉血气含量的影响。结果表明:复方丹参注射液可对抗低氧所致肺动脉压升高,降低肺血管阻力;心输出量和每搏输出量皆明显高于对照组;同时可改善缺氧动物动脉血氧分压和降低严重缺氧所致心电图ST段下移程度。

In the present experiment,the hemodynamic effect of Salvia miltiorrhizae composite injection (SMCI)on pulmonary and systemic circulation during hypoxic pulmonary arterial hypertension was observed.The results showed that the pulmonary arterial pressure increased at first in both group, then decreased gradually,but in SMCI group decreased much more than in the control group.The pulmonary vascular resistance increased very significantly in the control group,but in SMCI group considerably decreased after administration,then keeping at a level little more than the normal. Difference between groups was very significant.The stroke volume increased slightly at first and then decreased persistently in the control group,but increased significantly and kept at a higher level. in SMCI group.The protective effects of SMCI on hypoxic myocardium was studied by observing ST-segment on ECG.It was found that the ST-segment fell in both groups,but the degree of fall in SMCI was much less then in the control group.It was found that the PaO_2 was 35.1±2.6 in the control group,38.1±2.4 in SMCI group.Difference between groups was significant (P<0.05.) The above results suggest that SMCI can diminish hypoxic pulmonary vasoconstriction,improve PaO_2 in hypoxic animal and protect hypoxic myocardium.Hence,SMCI can be used to prevent and treat hypoxic pulmonary arterial hypertension.