摘要
研究了一种合成松果体素的简便方法 ,以 1 ,3 二溴丙烷为起始原料 ,经过重氮化 ,Fis cher环化 ,开环和脱羧以及乙酰化等 5步反应 ,制备得到松果体素 ,总收率达 2 7.8% 。
A convenient method of synthesis of melatonin using 1,3-dibromopropare as main starting material was studied. It consisted of five steps including diazotization, Fischer cyclization, ring opening, decarboxylation, and acetylation with 27.8% total yield. The reaction process and mechanism of Fischer reaction were also discussed.
出处
《浙江工业大学学报》
CAS
2001年第1期9-13,共5页
Journal of Zhejiang University of Technology