地塞米松治疗急性缺血性脑卒中的临床疗效评价

Evaluation of Dexamethasone in Treating Acute Cerebral Stroke

目的:研究糖皮质激素在急性脑梗死中所起的作用。方法:将76例急性脑梗死患者分为两组,第1组给予地塞米松10mg静点+血塞通0.4g静点+胞二磷胆碱0.5g静点。第2组除不给地塞米松外其它治疗同第1组(基础用药组),观察5～7天。结果:加用地塞米松组治疗后,颅CT检查提示梗死灶加大,神经功能损害明显增加。而基础用药组则无明显变化,神经功能损害减轻。结论:早期用地塞米松对急性缺血性脑卒中有不利影响。

To evaluate the effect of glucocorticoid on the treatment of acute cerebral stroke. Methods: Seventy-six patients with acute cerebral infarction were randomly divided into two treatment groups which included the group of intravenous infusion with dexamethasone 10 mg,Xuesaitong 0.4 g,and sodium citicoline 0.5 g Qd,and the group without dexam-ethasqne treatment. Results:The infarction area enlarged on CT scan and the deficits of neural function accelerated in dexamethasone group. There was no change on CT scan and no neural function deterioration in patients without dexamethasone treatment. Conclusion:Side effect is obtained with the early use of dexamethasone for the treatment of acute ischemic cerebral stroke.