系统性红斑狼疮患者血清IV型胶原和层粘连蛋白测定的意义

The Value of Detecting Laminin and Collage IV in Sera of Patients with Systemic Lupus Erythematosus

为探讨血清IV型胶原 (IV C)和层粘连蛋白 (LN)在系统性红斑狼疮 (SLE)患者中的临床意义 ;我们采用放射免疫法(RIA)对 34例SLE和 6 3例正常人的血清IV C和LN含量进行了测定 ,并进行治疗前后对比以及血清IV C和LN水平与其它临床指标间的直线相关关系分析。结果发现SLE组血清IV C和LN均较对照组显著升高 (P <0 0 0 0 1) ;治疗后随病情缓解较治疗前明显降低 (分别为P <0 0 0 1;0 0 0 5 )。血清LN与血清白蛋白呈显著负相关 (P <0 0 0 1) ,与 2 4h尿蛋白定量、血清免疫球蛋白M和补体C3水平之间呈明显的正相关 (P <0 0 5 ) ;血清IV C与血沉呈显著正相关 (P <0 0 5 )。上述结果提示血清IV C和LN水平在SLE患者中普遍升高 。

To explore the clinical value of laminin (LN) and collage IV(IV C) in sera of patients with systemic lupus erythematosus (SLE),a sensitive radioimmunoassay was utilized to detect the level of IV C and LN in sera of 34 patients with SLE and 63 with normal It was found that the levels of IV C and LN in SLE elevated significantly and were obviously higher than that in normal( P <0 0001) and after therapy the level of IV C and LN in SLE were significantly reduced ( P <0 001;0 005) There is a negative correlation between sera LN and albumin ( P <0 001),a positive correlation between sera LN and immunoglobulin M,complement C3 and amount of proteinuria in 24 hours ( P <0 05),a positive correlation between sera IV C and erythrocyte sedimentation rate ( P <0 05) These results showed sera IV C and LN were generally increased in SLE and may be important reference factors in evaluating the activity of SLE