腹水多参数检测在原发性肝癌中的诊断价值

The Value of Multiple Indexes Detection in Abdominal Water for DiagnosingPrimary Carcinoma of the Liver

目的 探讨腹水生化及免疫学检测在原发性肝癌诊断中的意义。方法 对 1 6例原发性肝癌患者的腹水进行 1 0项指标检测 ,并以 2 2例肝硬化患者作为对照组。结果肝癌组纤维蛋白降解产物 (FDP)、铁蛋白 (FeP)明显高于肝硬化组 (P <0 .0 1 )。腹水比重 (d)、癌胚抗原 (CEA)、乳酸脱氢酶 (LDH)和胆固醇(CH) ,肝癌组高于肝硬化组 (P <0 .0 5)。蛋白定量 (P)、纤维连结蛋白 (FN)、溶菌酶 (LIM )和 β2 -微球蛋白 (β2 -m)两组间无显著差别 (P>0 .0 5)。结论 腹水d ,FDP ,LDH ,CH ,CEA和FeP的敏感性、特异性均较高 ,对诊断原发性肝癌有一定价值 ,联合检测效果更佳。而腹水P ,LIM ,FN和β2

Objective To explore the value of some biochemical and immunological indexes in abdominal water on the diagnosis of primary carcinoma of the liver. Methods The ten indexes in Abdominal water of 16 patients with primary carcinoma of the liver and 22 patients with cirrhosis of liver were detected by clinical routine methods. Results The levels of FDP and FeP in primary carcinoma of the liver group were obviously higher than those in cirrhosis of liver group (P<0.01) The levels of Specific gravity, CEA, LDH and CH in pri-mary carcinoma of the liver were higher than those in cirrhosis of liver (P<0.05). The sensitivity and speciality above six indexes were also increased . In the indexes of P, FN, LIM andβ 2-m, there were no significant differences between the two groups (P>0.05). Conclusion The indexes of Specific gravity, CEA, FDP, CH, LDH and FeP in the abdominal water are significant for diagnosing primary carcinoma of the liver. The indexes of P, LIM, FN andβ 2-m may be not important indexes.