p16基因在涎腺腺样囊性癌中的表达及临床意义

p16 EXPRESSION AND ITS CORRELATION WITH LUNG METASTASIS IN HUMAN SALIVARY ADENOID CYSTIC CARCINOMA

目的 为了探讨p16基因在涎腺腺样囊性癌中的表达及其与肺转移的关系。方法 应用ABC免疫组化染色方法 ,研究转移抑制基因p16表达产物在 36例涎腺腺样囊性癌 (ACC)组织中的表达。结果 p16在ACC中有较高表达 ,阳性率为 5 8 3 % (2 1/ 36 ) ;其中有肺转移者阳性率为36 6 % (4 / 11) ,临床无肺转移者阳性率 76 % (19/ 2 5 ) ,差异有极显著意义 (P <0 0 1) ;p16表达与临床分期有关 ,分期越高 ,阳性率越低 ,早期 10 0 % (17/ 17)和Ⅲ、Ⅳ期 47 3 % (9/19)相比则有极显著性差异 (P <0 0 1)。与病理分型本组无显著相关 (P >0 0 5 )。结论 本实验结果表明p16基因在人ACC肺转移过程中起到抑制转移的作用 。

Objective To investigate p16 gene expression in salivary adenoid cystic carcinoma (ACC) and the relation between p16 gene expression and lung metastasis. Methods p16 gene protein was detected in 36 cases of ACC by ABC immunohistochemical method. Results 58 3 % (21/36) cases showed positive staining. Higher incidence for positive staining was found in ACC without lung metastasis 76 % (19/25) than those with lung metastasis 36 6 % (4/11) with remarkable statistical difference. Expression of p16 was correlated with the P TNM stageing ( P <0 05), but was not with pathologic pattern ( P >0 05). Conclusion The p16 gene may play an important role in suppressing the expression of metastatic potential in human salivary ACC.