直肠癌组织中维生素D受体表达的研究

EXPRESSION OF VITAMIN D RECEPTOR IN RECTAL CARCINOMA

目的 探讨直肠癌组织中维生素D受体 (VDR)表达的高低及其与肿瘤生物学行为之间的关系。方法 采用免疫组化结合显微光度测量计算机图象分析技术 ,对 2 1例直肠癌癌组织中VDR的表达与正常大肠粘膜进行比较。结果 直肠癌组织VDR表达平均IOD值 2 42 1± 0 6 6 7,显著低于正常大肠粘膜 5 993± 0 6 41(P <0 0 1) ;癌组织VDR的表达在不同的年龄、性别、Dukes分期、组织学分型、肿瘤生长方式、浸润深度之间无显著性差异 ;VDR表达与癌组织分化程度之间有密切联系 ,高分化、中分化、低分化三组VDR表达依次降低且差异显著。结论 直肠癌组织中VDR表达下降 ,且与分化程度密切相关 ,这种低表达状态 。

Objective To evaluate the level of Vitamin D receptor (VDR) expression in rectal cancer and its relation with clinico pathologic features. Methods 21 cases of rectal cancer entered this study. The vitamin D receptor expression of the cancer tissue and the normal mucosa 10 cm above the proximal resection margin were detected by immunohistochemical method, microspectrophotometer and computor image analysis. Results The VDR expression of cancer tissue (2 421±0 667) was significantly lower than that of the normal musosa (5 993±0 641) ( P <0 01). There was no significant correlation of VDR expression of carcinoma with the sex, age, histological classification, Dukes stage, the mode of tumor growth and infiltration depth. A significant correlation was found between the VDR expression and differenciation grade of the carcinoma. Well differentiated carcinoma had the highest level of VDR expression.Conclusion The low expression of VDR may be one of the reasons for the uncontrolled proliferation and poor differentiated status of rectal carcinoma and also one of the biological features of rectal carcinoma.