γ干扰素治疗恶性胸腹腔积液的临床观察

A PRELIMINARY CLINICAL OBSERVATION OF INTERFERON-γ TREATMENT OF MALIGNANT PLEURAL AND PERITONEAL EFFUSIONS

目的 观察γ干扰素治疗恶性胸腹腔积液的疗效。方法 经病理或细胞学证实的恶性胸腹水患者 5 6例 ,尽量抽 (放 )净患者胸腹水后 ,胸腹腔内注入γ干扰素 2 0 0～30 0万U + 0 .9%盐水 2 0ml,视胸腹水多少 ,5～ 10天后再重复治疗。结果 恶性胸水患者 46例 ,CR :17(37 0 % ) ,RP :17(37 0 % ) ,NC :12 (2 6 0 % ) ,总有效率 :CR +PR :34(74 0 % )。恶性腹水患者 10例 ,CR :2例 ,PR :4例 ,NC :4例。结论 γ干扰素治疗恶性胸腹腔积液发挥了生物反应调节剂局部治疗的优势 。

Objective To evaluate the efficacy of interferon γ (IFN γ) for malignant pleual and peritoneal effusions. Methods 56 patients with malignat effusion including 46 cases of pleural effusion and 10 cases of peritoneal effusion, were diagnosed by cytology or pathology or AFP positive. (2～3)×10 6U of IFN γ was injected into pleural or peritoneal cavity after the effusion was drained up. The treatment could be repeated 5-10 days later according to the amount of the effusion.Results 46 patients with pleural effusion showed CR 17 cases (37.0%), PR 17 cases (37.0%),NC 12 cases (26.0%); the total response rate was 74.0%. 10 patients with peritoneal effusion showed CR 2/10, PR 4/10, NC 4/10. Conclusion INF γ is one of selective treatments for malignant pleural and peritoneal effusions.