气虚、气滞在冠心病心血瘀阻证的发病作用研究

Influences of Qi Deficiency and Qi Stagnation in the Pathogenesis of Coronary Heart Disease with Heart-Blood Stagnation Syndrome

【目的】探讨在冠心病心血瘀阻证的发病中 ,气病致瘀的气滞心血瘀阻证和气虚心血瘀阻证的异同。【方法】在冠心病心血瘀阻证的患者中分别对气滞心血瘀阻证、气虚心血瘀阻证间的内皮素 (ET)、一氧化氮 (NO)、血栓素B2 (TXB2 )、 6-酮 -前列腺素F1α ( 6-Keto -PGF1α)、血液流变学、血小板聚集率、心钠素(ANF)、高频心电图和心功能等指标进行了观测比较。【结果】气滞心血瘀阻证各指标的改变轻于气虚心血瘀阻证。【结论】气滞心血瘀阻证病情相对较轻 ,是冠心病心血瘀阻证的初发阶段 ,气虚心血瘀阻证的病情较重 。

Objective To compare the pathogenesis of coronary heart disease (CHD) with heart_blood stagnation syndrome (HBSS) due to Qi deficiency and Qi stagnation. Methods Indices such as endothelin,NO,TXB 2 ,6-Keto-PGF 1α ,blood rheology,platelet aggregation rate,atrial natriuretic factor,high_frequency electrocardiogram and cardiac function were observed. Results The changes of the above indices in CHD with HBSS due to Qi stagnation (Group A)were smaller than those due to Qi deficiency(Group B). Conclusion Qi stagnation is the primary stage of CHS with HBSS,the pathological changes being mild;Qi deficiency is the advanced stage,the pathological changes being severe.