胆囊切除预防切口感染的探讨

THE EXPLORATION OF PREVENTION OF WOUND INFECTION IN CHOLECYSTECTOMY

目的：探讨胆囊切除术病人预防应用抗生素的时机和适应症。方法：304例胆囊切除病人分组对照。结果：预防组与对照组切口感染率比较，χ^2＝8．5，P＜0．01，高危易感组切口感染率比较，χ^2＝7．1，P＜0．01，低危组切口感染率比较，χ^2＝0．4，P＞0．05，预防用药时间不同之切口感染率比较χ^2＝0．02，P＞0．05。结论：存在高危易感因素的病人抗生素预防应用能明显降低术后切口感染率。麻醉诱导期开始用药，用药时间不宜超过术后2d，庆大霉素及甲硝唑可作为道选药物。

Objective:To explore the timing and indications of preventive antibiotics-using cholecystectomy.Methods:304 cases of cholecystectomied patients were divided into 4 groups and compared.Results:Compare wound infection rate of preventive group with that of control group,χ 2=8.5,P<0.01,with that of group having more infectious chance,χ 2= 7.1 ,P<0.01,with that of group having less infectious chance,χ 2=0.4,P>0.05.Compare wound infection rate of all patients that have different preventive medicine-using time,χ 2=0.02,P>0.05.Conclusion:preventive antibiotics-using in group having more infectious chance can decrease postoperative wound infection rate apparently.Medicine should be used from anesthesia induction period,and using time shouldn't excess 2 days.Of all medicines,gentamicin and metronidazole are preferable medicines to choose.