乳酸左氧氟沙星与头孢曲松钠治疗急性胆囊炎临床对照研究

Clinical comparison of efficacies of levofloxacin lactate and ceftriaxone in treatment of acute cholecystitis

观察国产乳酸左氧氟沙星注射液治疗急性胆囊炎的疗效及安全性。 6 0例急性胆囊炎患者随机分成乳酸左氧氟沙星 (L VL XL)组 30例和头孢曲松钠 (CRO)组 30例 ,入院时给药 ,用法为 L VL XL 2 0 0 mg,每日2次 ;CRO2 .0 g,每日 2次 ,术后继续相同给药 ,时间为 2～ 3d;结果 L VL XL 组与 CRO组的临床总有效率分别为 93.33%、90 .0 0 % ,对致病菌敏感率分别为 87.88%、90 .91% (无统计学差异 ) ,不良反应发生率为 6 .7%、6 .7% (无统计学差异 ) ,且反应轻微 ,呈一过性 ,患者可耐受。提示乳酸左氧氟沙星是一个安全有效的治疗急性胆囊炎抗菌药物。

To evaluate the efficacy and safety of levofloxacin lactate injection in treating acute cholecystitis. A tltal of 60 patients with acute cholecystitis were divided into 2 random groups and treated with levofloxacin lactate 200mg bid (30 cascs) or ceflriaxone sodium 2g bid (30 cases) when hospitalized until 2~3 days after operation. Results: The overall efficacy rate of LVLXL group and ceftraxone were 93.33% (28/30) and 90% (27/30); sensilivity rate of bacteria to levofloxacin and ceftriaxone were 87.88 (29/33) and 90.91% (30/ 33); adverse drug events rate was 6.7% (2/30) and 6.7% (2/30) respectively, no significant differences was noted between levofloxacin and ceftriaxone groups. All adverse events were generally mild and well tolerated. Conclusions: Levofloxacin lactate is effective and generally well tolerated in the treatment of acute cholecystitis.