氧化胁迫与精子功能损伤

Oxidative Stress and Defective Sperm Function

人类精子对氧化胁迫特别敏感 ,损伤精子功能的氧化胁迫有两个细胞来源 :精子自身和白细胞。由于精子膜含有高浓度的不饱和脂肪酸 ,而且精子自身的抗氧化能力很弱 ,在过量活性氧的攻击下 ,易发生脂类过氧化反应 ,使精子膜的流动性和完整性受到损伤 ,进而破坏精子功能 ,并最终引起男性不育。此外 ,过量的活性氧还可造成精子核DNA的损伤 ,而父代精子DNA的损伤又与子代儿童癌症的发生有密切的关联。

Human sperm is susceptible to oxidative stress originated from two distinct cellular sources, leucocytes and spermatozoa. Since human sperm plasma membrane consists of a high concentration of unsaturated fatty acids and sperm itself has weak antioxidant properties, it could be attacked by the excess reactive oxygen species (ROS). As a consequence of lipid peroxidation, the sperm plasma membrane lose their fluiditys and integrity and the spermatozoa lose their function. The excess ROS can also attack the DNA in the sperm nucleus. There exists a close linkage between the oxidative DNA damage in sperm and the high incidence of cancer in the offspring. Ntl J Androl,2001,7(1):40～43