2型糖尿病患者肾小球区的病理改变

Pathologic Changes on Glomerulic Area in Non-Dependent Diabetes Mellitus(Type 2 DM) Patients

目的 探讨 2型糖尿病患者肾小球系膜区基质与肾小球硬化及肾脏损害程度的关系。方法 利用免疫组化Lumininl和LSAB染色技术 ,对 2 1例 2型糖尿病患者和 12例对照组尸检肾组织进行检测 ,并用计算机图像分析系统对Ⅳ型胶原进行定量分析。结果 Ⅳ型胶原的数量在 2型糖尿病患者肾组织中明显增加 ,与肾小球硬化及入球小动脉硬化关系平行 ,但在肾功能衰竭患者中增加不明显。结论 基质增多是糖尿病肾小球硬化早中期表现的特征 ,定量测定可以作为判断肾脏损害程度的一项指标。

Objeetive To explore the relationship among the glomerular mesangium components,degree of renal lesion and glomerulosclerosis in patients with type 2 DM.Method A quantitative study of type Ⅳ collagen in kidneys taken from twenty-one patients with type 2 DM and ten-two control autoptical renal tissue specimens were investigated by immunochemical techniques,computer image analysis system.Results The amounts of type Ⅳ collagen were increased parallel with advances of glomerulosclerosis and renal arteriolosclerosis in patients with type 2 DM,but the collagen had not obviously elevation in renal failure patients.Conclusions The increased type Ⅳ collagen is a characteristic manifestation of early and moderate lesions of glomerulosclerosis in type 2 DM.Quantitative determination of glomerular mesangium components could be a good index to judge the lesion degree of kidney.