胆囊腺肌症p53、bcl-2、EGFR蛋白的表达

The Overexpression of p53,bcl-2,EGFR Oncoproteins in Tissue of Adenomyomatosis

目的 为探索胆囊腺肌症与胆囊癌的关系。方法 用免疫组化 (S -P)法对胆囊癌、胆囊腺肌症、慢性胆囊炎进行了 p53、bcl - 2、EGFR蛋白的检测 ,并对其临床病理关系进行讨论。 结果 p53、bcl - 2、EGFR在慢性胆囊炎、胆囊腺肌症、胆囊癌表达的阳性率有显著差异 ,胆囊癌中表达率高于慢性胆囊炎、胆囊腺肌症 ,而胆囊肌症与慢性胆囊炎的表达率无显著差异。结论 提示p53、bcl- 2、EGFR在胆囊癌组织的表达具有广泛性 ,胆囊腺肌症作为癌前期病变证据尚不充分。

Objective To explore the relationship between cholecystoadenomyomatosis and gallbladder cancer.Method The expression of p53,bcl-2,EGFR oncoproteins were examined by method of immunohistochemistry in benign lesions and carcinomas in gallbladder.Results The study revealed that overexpressions of p53,bcl-2,EGFR oncoproteins were detected in 0,4,3 cases of 21 patients with chronic cholecystitis;0,5,3 cases of 20 patients with cholecysto-adenomyomatosis and 16,14,11 cases of 25 patients with adenocarcinoma of the gallbladder respectively.There were significantly differences in single or multiple oncogene expression rates among groups,but not in chronic cholecystitis to adenomyomatosis.Conclusions These results suggests that oncogenic changes of p53,bcl-2,EGFR expression may play a role in gallbladder oncogenesis,cholecystoadenomyomaltosis should not be considered as an important precancerous lesion of gallbladder.