幽门螺杆菌感染与霜斑样病变形成及转归关系的临床研究

A Clinical Observation on the Relationship Between Shimofuri Lesion with Helicobacter Pylori Infection

目的 了解幽门螺杆菌 (Hp)感染在霜斑样病变的形成与转归的作用。方法 检测了接受胃镜检查 192例病人胃窦和球粘膜Hp及球粘膜炎症 ,分析球部Hp与这些指标的关系。把志愿复查的霜斑样病变患者随机分为雷尼替丁与抗Hp治疗组后重复胃镜观察。结果 球部Hp的检出率 ,在不同病变间存在显著差异 (P<0 0 5) ,与胃窦Hp密度相关 (rs=0 556 6 ,P <0 0 5) ;球粘膜炎症程度也存在显著差异 (P <0 0 5) ,与球部Hp定植密度相关 (rs=0 56 15,P <0 0 5)。 2 6例Hp感染的霜斑样病变复查胃镜 ,抗Hp治疗效果显著 (P <0 0 5)。结论 霜斑样病变可能与十二指肠球部Hp定值有关 ,受胃窦HP密度的影响。

Objective To learn the roles of Helicobater pylori(Hp) colonization in shimofuri lesion formation of degestive tract and its transformation.Method Infective rate of Hp in biopsy specimens of gastric antrum and duodenum,degree of inflammation of the duodenal bulb mucosas were measured,and analyzed relationship of these indexes with Hp colonization in duodenal bulb mucosas,all of patients with shimofuri lesion were randomly divided into ranitidine suppressing acid group(ranitidine group) and anti-Hp therapy group(anti-Hp group),then two groups were secondly observed with gastroscope.Results The positive rate of Hp colonization in duodenal bulb was significantly difference in various phases of the disease(P<0 05),it was correlated to the density of Hp in gastric antrum(r s=0 566,P<0 05):The inflammation degree between various duodenal mucosa lesion was different(P<0 05) and correlated with the Hp infection in duodenal mucosas(r s=0 5615,P<0 05).twenty-six cases of Hp-infecting shimofuri lesions were repeated examined by endoscopy and the endoscopic findings were five cases of shimofuri lesion(one case complicated duodenal ulcer)in the ranitidine group,but it was zero in anti-Hp group(P<0 05).Conclusion The results suggest that the shimofuri lesion is associated with Hp colonization in duodenal bulb,and also related to the Hp density in gastric antrum.