急性缺氧对豚鼠40Hz听觉相关电位的影响

Acute Anoxia on 40 Hz Auditory Event Related Potential in Guinea Pigs

目的 探讨急性缺氧条件下豚鼠４０Ｈz听觉相关电位的改变。方法 利用气管插管辅助呼吸并给予不同浓度低氧气体建立动物模型，观察在不同程度的急性缺氧条件下，豚鼠４０Ｈz听觉相关电位的改变。结果 轻度缺氧条件下４０Ｈz听觉相关电位各项参数无明显改变，加重缺氧则其阈值升高，各波平均振幅降低，Ｐ１波潜伏期延长。结论４０Ｈｚ听觉相关电位在轻度缺氧条件下比较稳定，这可能与４０Ｈz听觉相关电位本身的特性有关，严重缺氧则表现为抑制。

Objective To investigate the changes of 40 Hz auditory event related potential(40 Hz AERP) in guinea pigs under acute anoxia. Methods Acute anoxia of different degree was imposed on guinea pigs and the changes of 40 Hz auditory event related potential (40 Hz AERP) were observed. Results When suffered from mild anoxia, no obvious changes of 40 Hz AERPs were observed. If the anoxia was severe, the threshold of 40 Hz AERP was elevated, and the average amplitude of P1-4 was enlarged, the P1 latency was also prolonged. Conclusion 40 Hz AERP showed its stability under mild anoxia, which might be due to the electrophysiologic characteristics of 40 Hz AEPR, and under severe anoxia, it became obviously inhibited.