舒通胶囊急性毒性实验

Acute Toxicity Test of Shutong Capsule

目的 :观察研究舒通胶囊的毒性 ,为临床应用提供依据。方法 :给实验小鼠灌服不同浓度的舒通胶囊水提液 ,测定小鼠灌胃最大耐受量 ;采用改进寇氏法 ,测定实验小鼠腹腔注射半数致死量 (L D5 0 )。结果 :实验小鼠灌胃给药的最大耐受量倍数为 137倍 ,超过人口服量的 10 0倍 ;腹腔注射半数致死量 (L D5 0 )为 (6 6 .2 0± 7.0 1) g· kg- 1。结论

Objective: To observe the toxicity of Shutong capsule and provide basis for clinic use. Methods: Gave experiment mice different concentration water extracts of Shutong capsule, then determined the maximum torlerant dose; with improved Core's method, determined LD 50 by ip. Results: the maximum tolerant dose of mice was 137 times which was 100 times higher than the man's oral dose. LD 50 (IP) was (66.2±7.01) g·kg 1 . Conclusions: The dose of Shutong capsule was safe in clinic use.