三叉神经痛患者血浆β-内啡肽含量的观察

Observation of Plasma Levels of β-Endorphin in Patients with Trigeminal Neuralgia

目的 确定血浆 β 内啡肽与三叉神经痛发病的关系。 方法 用放射免疫法检测 12例患者疼痛发作时患侧颈外静脉血、健侧颈外静脉血、肘静脉血及术后患侧颈外静脉血中 β 内啡肽含量 ,12例正常自愿者颈外静脉血中β内啡肽含量作为正常对照。 结果 患者血浆 β 内啡肽含量显著低于正常人 (P <0 0 5 ) ;疼痛发作时患侧颈外静脉血中 β 内啡肽含量与健侧颈外静脉血、肘静脉血中 β 内啡肽含量无显著差异 ,与术后患侧颈外静脉血中 β 内啡肽含量也无显著差异 (P >0 .0 5 )。结论 三叉神经痛患者血浆 β 内啡肽含量降低 ,中枢内源性痛觉调制系统对疼痛的抑制作用可能减弱 ,外周神经源性炎症可能得不到有效的控制。

Objective To observe the relationship between plasma levels of β endorphin and trigeminal neuralgia. Methods During the attacks of trigeminal neuralgia, β endorphin levels of plasma from external jugular, cubital fossa vein blood ipsilateral to the pain and contralateral external jugular vein blood were assessed by sensitive radioimmunoassay in 12 cases, after operations the venous blood from the ipsilateral external jugular vein was sampled again, the external jugular vein blood of 12 normal volunteers was collected as control. Results The plasma levels of β endorphin in patients with trigeminal neuralgia were significantly lower than that in normal volunteers( P <0.05). Conclusion The lowered plasma β endorphin levels may be an important factor for the development of pain in patients with trigeminal neuralgia, which may result in pain and neurogenic inflammation that can not be controlled in central nervous system and peripheral nerve terminals. [