血液净化救治毒鼠强中毒患者的临床研究

Clinical study of blood purification therapy in patients with acute tetramine intoxication

目的 :探索血液净化对毒鼠强中毒的治疗价值。方法 :应用血液净化方法治疗 10例毒鼠强中毒患者 ,进行疗效总结 ;并与既往常规治疗 (未血液净化 )的 7例患者疗效进行比较。结果 :血液净化治疗后患者血液毒鼠强浓度、心肌酶、APACHE 评分、脑电图评分较治疗前均有明显降低 (P均 <0 .0 1) ;血液净化组与常规非血液净化治疗组患者比较 ,相同时期 (入院第 5日 )内血液毒鼠强浓度下降值〔分别为 (82 .3± 2 1.7)μg/ L和(2 7.9± 14.2 )μg/ L〕有显著差异 (P<0 .0 1) ,意识转清醒及抽搐停止时间〔血液净化组分别为 (5 .7± 2 .6 )小时和 (0 .9± 0 .7)日 ,非血液净化组分别为 (16 .2± 10 .1)小时和 (4 .5± 3.7)日〕均显著提前 (P均 <0 .0 1)。结论 :血液净化治疗毒鼠强中毒比常规方法更有效。

Objective:To explore the clinical efficacy of blood purification therapy in acute tetramine intoxication (ATI).Methods:Ten ATI patients were treated with blood purification and the clinical effect was evaluated.The clinical results were also compared with conventional therapy (nonblood purification) in 7 patients.Results:The clinical effect of blood purification therapy was satisfactory.Blood concentration of tetramine,myocardial enzymes,APACHEⅡscore,EEG score were significantly decreased (all P <0 01).Blood tetramine concentration in patients with blood purification was significantly lowered than that in patients without blood purification 〔(82 3±21 7)μg/L vs.(27 9±14 2)μg/L, P <0 01〕.Meanwhile,duration of consciousness recovery and convulsion termination were significantly shortened in blood purification group compared with conventional therapy group 〔consciousness recovery:(5 7±2 6)hours vs.(16 2±10 1) hours, P <0 01;convulsion termination:(0 9±0 7)days vs.(4 5±3 7) days, P <0 01〕.Conclusions:Blood purification therapy is better than conventional therapy in patients with ATI.