胸腺嘧啶核苷磷酸化酶与子宫内膜癌关系的研究

A study on thymidine phosphorylase in endometrial carcinoma

目的 :探讨胸腺嘧啶核苷磷酸化酶 (TP)与子宫内膜癌的临床病理特征、无瘤生存率、微血管密度 (MVD)的关系。方法 :采用免疫组织化学方法检测 40例子宫内膜癌蜡块组织中的TP的表达水平及MVD。结果 :TP阳性肿瘤的MVD明显高于TP阴性肿瘤。病理分级G1的TP阳性率明显高于G2 、G3 ,肌层未受累或侵犯肌层≤ 1/ 2的TP阳性率明显高于侵犯肌层 >1/ 2者 ,手术分期Ⅰ期、Ⅱ期总的TP阳性率明显高于Ⅲ期。结论 :TP具有促血管增生作用 。

To study the relationships between the expression of thymidine phosphorylase (TP),the density of microvessels(MVD)of the tumor,the clinical and pathological features and tumor free survival rate in endometrial carcinoma.Methods:The expression of TP and the intratumor MVD were determined by immunohistochemistry.Results:Of the 40 tumors,24(60%) were TP positive.MVD was significantly higher in TP positive tumors than that in TP negative tumors.TP positive rate was significantly higher in those cases that myometrium invasion without invasion or with invasion not exceeding 1/2 than that in those cases with invasion exceeding 1/2;in those cases of G 1 grade than that in those cases of G 2 and G 3,and in those cases of stages Ⅰ and Ⅱ than that in those cases of stage Ⅲ.There was no significant correlations between TP and menopausal status,estrogen receptor,progesterone receptor,lymph node metastasis and tumor free survival rate.Conclusion:TP played an important role in angiogenesis,especially in the early stage or well differentiated endometrial carcinoma.