摘要
目的 观察尿激酶对急性心肌梗死 (AMI)患者血浆 -内皮素 -肾素 -血管紧张素 -心钠素系统(ERAANPS)的影响。方法 用放射免疫法测定AMI患者和正常对照组的血浆内皮素 (ET)、肾素活性 (PRA)、血管紧张素Ⅱ (ATⅡ )、心钠素 (ANP)的浓度。结果 与对照组相比 ,AMI后ERAANPS活性明显增强 ;尿激酶可使ET、PRA、ATⅡ浓度升高 ,与对照组相比具有显著性差异 (P <0 0 5 )。结论 急性心肌缺血坏死可激活ERAANPS ;
Objective To observe the changes of plasma endothelin-renin angiotensin-atrial natriuretic peptide system(ERAANPS) after acute myocardial infarction(AMI)and the effects of thrombolytic agent.Methods Plasma concentration of endothelin, renin activity, angiotensinⅡ and atrial natriuretic peptide were measured in patients after AMI and normal cases with radioimmunoassay.Results The activity of ERAANPS elevated significantly in patients with AMI. The plasma concentration of ET、PRA、ATⅡ increased significantly after thrombolysis(P<0 05).Conclusion The ERAANPS is stimulated at myocardial ischemia and necrosis. Thrombolytic agent can significantly enhance it.
出处
《中国全科医学》
CAS
CSCD
2001年第4期273-274,共2页
Chinese General Practice
