聚乙烯吡咯烷酮对药物与β-环糊精包合作用的影响

Effect of Polyvinylpyrrolidone on Complexation of Drug and β-cyclodextrin

研究了聚乙烯吡咯烷酮 (PVP)对药物与 β 环糊精 (β CD)包合作用的影响。测定了氯霉素、巴比妥在不同温度、不同浓度PVP和 β CD水溶液中的溶解度及其热力学参数。实验发现PVP增强了巴比妥与 β CD的包合作用 ,3 .0 g/LPVP的加入使包合物形成常数增加了 6 7% ;但却对氯霉素与 β CD的包合起阻碍作用 ,降低了 β CD对氯霉素的增溶效应。

The effect of polyvinylpyrrolidone(PVP) on the complexation of drugs with β cyclodextrin (β CD) were investigated. The solubilities of barbital and chloramphenicolum in aqeous β CD solution and in aqueous solution containing both PVP and cyclodextrin were determined. In aqueous solutions,PVP was shown to increase the solubilising effect of barbital in β CD . Addition of 3.0 g/L PVP resulted in a 67% increase in the stability constant of the complex. On the other hand,PVP was demonstrated to inhibite the cyclodextrin complexation of chloramphenicolum.