胰岛素抵抗与高血压患病率及血压水平的关系

The relation of insulin resistance to the prevalence of hypertension and blood pressure levels

目的 探索中国人群胰岛素抵抗与高血压患病率及血压水平的关系。方法 对北京石景山农民、首钢工人 ,年龄 45～ 6 4岁 ,共 3899人的空腹胰岛素与血压之间的关系进行现况调查。用方差分析方法判断不同胰岛素四等分组之间收缩压 ( SBP)、舒张压 ( DBP)均值的差别 ;以简、复相关分析法估计胰岛素对数值与收缩压、舒张压之间的相关系数 ;用 L ogistic回归分析法估计不同胰岛素四等分组的高血压发生的 OR值及其 95 %可信区间。结果 收缩压、舒张压均随着空腹胰岛素水平的升高而上升 ( P<0 .0 0 1) ,城市女性、乡村男性的收缩压、舒张压与血胰岛素水平呈极显著正相关 ,年龄调整后相关性依然存在 ,而年龄、体重指数调整后相关性消失。城市男性、乡村女性 SBP、DBP与血胰岛素水平无相关性。胰岛素四等分组的第 2、3、4等分组与第 1组比较的 OR及其95 %可信区间分别为 :1.16 9,0 .945～ 1.44 8;1.473,1.189～ 1.86 2 ;1.5 84,1.2 82～ 1.96 0。结论 在中国人群中胰岛素抵抗与高血压患病率有关 ,且随着胰岛素抵抗程度的升高 。

Objective To explore the relation of insulin resistance to the prevalence of hypertension and blood pressure levels.Methods A field investigation of the association of fasting insulin level with blood pressure level among Shijingshan peasants and the Capital Steelworks worker′s (3899,both sexes,aged 35～64) in Beijing was made.Variance analysis was used to examine the difference of SBP and DBP.Correlation analysis was used to estimate the correlation coefficient between insulin and SBP and DBP.Logistic regression analysis was used to estimate the OR value and its 95 % confidence intervals of the prevalence of hypertension in different quarter groups by insulin levels.Results SBP, DBP are elevated along with the elevation of fasting insulin level (P<0 001) . The OR values and 95 % confidence intervals are 1.169, 0.945～1.448; 1.473, 1.189～1.862; 1.584, 1.282～1.960. Conclusion There is relation between insulin resistance and the prevalence of hypertension and blood pressure levels,risks are regularly elevated along with the elevation of insulin resistance.