幽门螺杆菌感染与胃癌前病变的关系

Relation between Infection of Helicobacterium Polyrus and Precancerous Lesion of Stomach

目的 探讨幽门螺杆菌 (HP)与胃癌前病变的关系。方法 本文对以往因上腹不适来本院就诊的2 2 5例患者进行了幽门螺菌检测、胃镜检查和胃粘膜病理活检。结果 提示HP检出阳性率为 53.8%。HP感染时是胃粘膜腺体萎缩和肠上皮化生 (肠化生 )发生率分别为 9.1%和 14.9% ,显著高于无HP感染的胃粘膜萎缩和肠化生发生率 2 .9%和 7.7% (P <0 .0 5)。HP感染时发生胃粘膜萎缩及肠化生的平均年龄分别为 4 6 .6± 14.4岁及 39.3± 13.6岁 ,显著小于无HP感染时的胃粘膜萎缩及肠化生年龄 56 .2± 9.1岁及 58.2± 8.6岁(P <0 .0 1)。结论 提示早年感染HP可使胃粘膜萎缩及肠化生及非典型增生发生率增高 ,增加了患胃癌的危险性。

Objective To explore the relation between the helicobacterium polyrus (HP) and precancerous lesion of stomach. Methods 225 patients of epigastric disposition were received HP detection, gastroscopy and biopsy of gastric mucosa. Results The positive rate of HP detection was 53.8%. The incidences of atrophy of gland and intestinal metaplasis with HP infection were 9.1% and 14.9%. These were significantly higher than those 2.9% and 7.7% without HP infection (P<0.05). The average ages of occurrence of mucous atrophy and intestinal metaplasis with HP infection were 46.6±14.4 and 39.3±13.6. These were significantly less than those 56.2±9.1 and 58.2±8.6 without HP infection (P<0.01). Conclusion The early infection of HP could increase the incidences of gastric mucous atrophy, intestinal metaplasis and atypical hyperplasia and increase the risk of suffering gastric cancer.