肥胖儿童红细胞钙镁水平及ATP酶活性与高血压关系的探讨

Relations between erythrocyte Ca^(2+),Mg ^(2+) levels and cell membrane ATPase activities in patients with hypertension in obese children

目的 探讨细胞离子代谢紊乱在肥胖儿童高血压发病中的作用。方法 测定 12 5例 (正常对照 37例 ,正常血压肥胖 34例 ,正常体重高血压 2 1例 ,高血压肥胖 33例 ) 12 16岁中学生的红细胞膜ATP酶活性、血浆和红细胞胞浆Ca2 + 、Mg2 + 水平。结果 正常血压肥胖组 (ONT)儿童红细胞膜Na+ K+ ATP酶和Ca2 + ATP酶活性较正常对照组 (NT)显著降低 ,正常体重高血压组 (NOHT)和高血压肥胖组 (OHT)两酶活性又显著低于ONT组。ONT组、NOHT组和OHT组红细胞胞浆Ca2 + 水平三组之间无显著差异 ,但均显著高于NT组。红细胞胞浆Mg2 + ,血浆Ca2 + 、Mg2 + 在NT组和ONT组之间无显著差异 ,在NOHT组和OHT组均显著降低。结论 红细胞膜Na+ K+ ATP酶和Ca2 + ATP酶活性降低可能在肥胖儿童高血压的发病机制中有重要作用。

Objective To explore the roles of the metabolic disorders of cellular ions in pathogenesis of hypertension in obese children.Methods Erythrocyte membrane ATPase activities,plasma and cellular Ca 2+,Mg 2+ levels were measured in 125(37 non-obese normotensives,34 obese normotensives,21 hypertensives and 33 obese hypertensives)middle school students aged 12~16 years.Results Erythrocyte membrane Na+-K+-ATPase and Ca 2+-ATPase activities were significantly lower in obese children with normotension than those in non-obese normotensive children,and they were also significantly lower in two groups of hypertensive children than those in obese children with normotension.Erythrocyte Ca 2+ in normotensive obese and two group of hypertensive children was significantly higher than that in non-obese normotensive children,but there were no significant differences between the three groups.There were no significant differences found in erythrocyte Mg 2+,plasma Ca 2+ and Mg 2+ between normotensive obese and normotensive non-obese children,but significant decreases were found in both groups of hypertensive children.Conclusion Decreased Na+-K+-ATPase and Ca 2+-ATPase activities may play important roles in pathogenesis of hypertension in obese children.