补碘和硒对克汀鼠红血球中的微量元素的影响

The influence of iodine and selenium supplementation on trace elemental contents in erythrocyte of the cretinism rats

用克汀病流行病区的粮食喂养大鼠 (克汀鼠 ) ,分成 4个组补硒、补碘、补碘同时补硒、和作为对照的低碘鼠 ,另取一正常对照组。补充 5周后 ,用PIXE法和XRF法测量它们红血球的微量元素 (K、Ca、Mn、Fe、Cr、Cu、Zn、Rb、Pb等 )。用放射性免疫法测定甲状腺激素指标 (T3、T4、FT3、FT4、rT3等 )。获得的数据用SPSS/PC单因素方差分析和相关性检验。结果表明 ,低碘鼠补碘、硒或同时补碘硒后 ,Zn、Mn、Cu和Rb的含量变化以及甲状腺激素指标T4、FT4和rT3比低碘鼠显著地升高。

The contents of K, Ca, Mn, Fe, Cr, Cu, Zn, Rb and Pb in the erythrocyte of 5 groups of rats, were measured by PIXE and XRF. Four groups of the cretinism rats were continuously fed the feed from epidemic cretinism area. Three groups among them drank the water with I and/or Se supplementation. Control group was normal rats fed normal feed. Five weeks later the blood samples were collected. The erythrocyte was separated for the determination of elemental concentrations, the serum for the radioimmunoassay of thyroid hormones T3, T4, FT3, FT4 and rT3 status. The comparison among five groups and the correlation between elements and thyroid hormones were performed by using SPSS/PC statistical package. The results showed that comparing with non-supplementation or control groups the concentrations of Zn, Mn, Cu, or Rb in the groups of I and/or Se supplementation were significantly fluctuating, while thyroid hormones T4, FT4 and rT3 significantly increased.