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中能碳离子束对不同贯穿深度上黑色素瘤B16细胞的辐照存活效应

Irradiated survival effect of melanoma B16 cells at different penetration depths of intermediate energy heavy-ion beams
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摘要 测量了 4 9.30MeV u及经脊形过滤器展宽的Bragg峰的 74 .55MeV u12 C离子束在不同贯穿深度上辐射后黑色素瘤B16细胞的存活率。结果显示 ,以存活为终点的B16细胞生物学效应与碳离子束能量沉积同步增大 ,即Bragg或展宽的Bragg峰区内细胞存活率远低于离子束入射或出射通道处的细胞存活率。通过实验测量与剂量平均LET结合的线性平方模型理论计算存活曲线的比较 ,发现在实验测量误差范围内两者符合较好。提示 Survival fractions of melanoma B16 cells at different penetration depths exposed to 49.30MeV/u 12 C ion beam and modulated 74.55MeV/u 12 C ion beam with a ridge filter to form a spread-out Bragg peak (SOBP) were measured. The results show the survival response of B16 cells as the biological endpoint to heavy ions increases synchronously with the deposited energy along the beam traversal, that is, the survival fraction near or at the Bragg peak or SOBP is far lower than that at the beam's entrance or exit channel. Comparisons of the experimental data with calculated survival fractions at different depths predicted by the linear-quadratic survival model combined with dose-averaged LET display a good agreement within the experimental errors. It is prompted that the linear-quadratic model combined with dose-averaged LET possibly is a valid way to calculate the survival effect of B16 cells along the beam penetration under the exposure of the intermediate energy heavy-ion beam.
出处 《核技术》 CAS CSCD 北大核心 2001年第4期277-282,共6页 Nuclear Techniques
基金 国家攀登计划 (B) !(85 - 45 - 0 1- 3)资助 甘肃省自然科学基金 !(A5 7)资助
关键词 细胞存活 贯穿深度 肿瘤 辐射治疗 中能碳离子束 黑色素瘤 B16细胞 辐射生物效应 Heavy ion beam, Spread-out Bragg peak beam, Cell survival, Penetration depth
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  • 1Sihver L,Adv Space Res,1995年,17卷,2期,105页
  • 2李强,卫增泉,李文建,周光明,党秉荣,蔡喜臣,何静,颉红梅,韩光武,黄涛,陈卫强,王菊芳,张树民.展宽重离子束的Bragg峰[J].高能物理与核物理,1998,22(7):646-650. 被引量:7

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