摘要
本研究检测了173例高血压病患者血浆中与调节血管平滑肌舒缩作用有关的血管活性物质,结果发现高血压病肝阳上亢型及阴虚阳元型呈环—磷酸腺苷(cAMP)、环—磷酸鸟苷(cGMP)升高,cAMP/cGMP 比值降低,血栓素 B_2(TXB_2)升高,心钠素(ANF)、P物质(SP)降低。用直线回归相关分析,舒张压与心钠素、舒张压与 P 物质均呈负相关。用平肝降压汤为主中西医结合治疗后,cAMP、cGMP、TXB_2呈降低,6-keto-PGF_(1α)、ANF、SP 升高,呈可逆性变化。显示了中西医结合治疗较中药组、西药组及安慰剂组的疗效为好。其疗效机理可能是通过调节血管平滑肌舒张因素而起作用。
In order to study the connection of diastolic activity of smooth muscles of blood vessels with development of hypertension,plasma cAMP,cGMP,TXB_2,6-K-PGF1α,ANP,SP were determined with radioimmunoassay,of 17a hypertension patients with Liver Yang(阳)exuberance (LYE) 91 cases,and Yin(阴)deficiency and Yang exuberance(YDYE) 82 cases.In addition,228 health subjects served as control.The results showed that the Ievels of cAMP,cGMP and TXB_2 in both LYE and YDYE groups were higher than those in the control group,but the levels of ANP,SP and cAMP/ cGMP ratio in LYE and YDYE groups were lower than those in the control.As to the level of 6-K -PGF1α,no significant variance was found between these groups.After TCM-WM treatment,the levels of cAMP,cGMP and TXB_2 in LYE and YDYE groups got down,as compared with those in the control,adversely the levels of ANP,SP and 6-K-PGF1α in LYE and YDYE groups turned up significantly.However the cAMP/cGMP ratio had no remarkable change between these groups.The linear regression analyses between the diastolic pressure and ANP or SP both proved negative correlation(r=-0.36,P<0.05;r=-0.35,P<0.05).The findings indicated that the TCM-WM treatment was the most effective among the therapies employed in the study,and that this therapy affected the diastolic activity of smooth muscles by modulating the above factors existing in the nervous and endocrine systems of the patients with hypertension.
