雌激素对绝经后妇女心血管高危因素的影响

Study on the influences of estrogen to the cardiovascular high risk factors of post menopausal women.

目的：研究雌激素对绝经后妇女心血管高危因素的影响。方法：对绝经后妇女１７例随机分为Ａ、Ｂ两组，Ａ组９例服用炔雌醇００２５ｍｇ／ｄ，Ｂ组８例服用炔雌醇００５ｍｇ／ｄ，共３个月。于服药前后在相同条件下测量身高、体重、腰围、臀围和测定血压，血糖、胰岛素、总胆固醇、甘油三酯、高密度脂蛋白胆固醇。结果：两组的总胆固醇和低密度脂蛋白胆固醇均降低，Ｂ组高密度脂蛋白胆固醇升高。但甘油三酯水平也增加，两组空腹血糖、胰岛素水平均降低。结论：雌激素有助于绝经后妇女的糖、脂代谢，对心血管系统有保护作用。炔雌醇的剂量以００２５ｍｇ／ｄ为宜。

bjective To study the effect of estrogen on cardiovascular high risk factors in postmenopausal women. Methods Postmenopausal women were randomized into two groups:nine cases of group A receiving 0.025mg/d ethinyl estradiol(EE) and eight cases of group B receiving 0.05mg/d EE for three months.The cardiovascular high risk factors were analyzed before and after EE administration respectively. Results Two kinds of EE dosage effectively decreased total cholesterol(TC) and low density lipoprotein cholesterol(LDL C).Group B increased significantly high density lipoprotein cholesterol(HDL C),while total triglyceride(TG) increased too.Two kinds of EE dosage reduced remarkably the fasting levels of plasma glucose and insulin. Conclusions The favourable effect of estrogen on glucose and lipid metabolisms in postmenopausal women is remarkable,if glucose and lipid metabolisms in postmenopausal women is remarkable.It may give protection to cardiovascular system and suggest that the use of 0.025mg/d EE should be the appropriate dosage.